3K5V

Structure of Abl kinase in complex with imatinib and GNF-2

3K5V の概要

• エントリーDOI: 10.2210/pdb3k5v/pdb
• 関連するPDBエントリー: 1OPJ
• 分子名称: Tyrosine-protein kinase ABL1, 3-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)benzamide, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (5 entities in total)
• 機能のキーワード: kinase, atp-binding, nucleotide-binding, oncogene, sh2 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm, cytoskeleton: P00520
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69258.34

構造登録者

Cowan-Jacob, S.W.,Fendrich, G.,Rummel, G.,Strauss, A. (登録日: 2009-10-08, 公開日: 2010-01-19, 最終更新日: 2023-09-06)

• 主引用文献: Zhang, J.,Adrian, F.J.,Jahnke, W.,Cowan-Jacob, S.W.,Li, A.G.,Iacob, R.E.,Sim, T.,Powers, J.,Dierks, C.,Sun, F.,Guo, G.R.,Ding, Q.,Okram, B.,Choi, Y.,Wojciechowski, A.,Deng, X.,Liu, G.,Fendrich, G.,Strauss, A.,Vajpai, N.,Grzesiek, S.,Tuntland, T.,Liu, Y.,Bursulaya, B.,Azam, M.,Manley, P.W.,Engen, J.R.,Daley, G.Q.,Warmuth, M.,Gray, N.S.; Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.; Nature, 463:501-506, 2010; PubMed: 20072125; DOI: 10.1038/nature08675

実験手法

X-RAY DIFFRACTION (1.74 Å)