3K3I

p38alpha bound to novel DGF-out compound PF-00215955

3K3I の概要

• エントリーDOI: 10.2210/pdb3k3i/pdb
• 分子名称: Mitogen-activated protein kinase 14, (3S)-3-[4-(4-bromophenyl)-1H-imidazol-2-yl]-1,2,3,4-tetrahydroisoquinoline, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total)
• 機能のキーワード: p38 kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40918.54

構造登録者

Kazmirski, S.L.,DiNitto, J.P. (登録日: 2009-10-02, 公開日: 2009-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Tecle, H.,Feru, F.,Liu, H.,Kuhn, C.,Rennie, G.,Morris, M.,Shao, J.,Cheng, A.C.,Gikunju, D.,Miret, J.,Coli, R.,Xi, S.H.,Clugston, S.L.,Low, S.,Kazmirski, S.,Ding, Y.H.,Cao, Q.,Johnson, T.L.,Deshmukh, G.D.,DiNitto, J.P.,Wu, J.C.,English, J.M.; The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.; Chem.Biol.Drug Des., 74:547-559, 2009; PubMed: 19843080; DOI: 10.1111/j.1747-0285.2009.00884.x

実験手法

X-RAY DIFFRACTION (1.7 Å)