3K3I
p38alpha bound to novel DGF-out compound PF-00215955
3K3I の概要
エントリーDOI | 10.2210/pdb3k3i/pdb |
分子名称 | Mitogen-activated protein kinase 14, (3S)-3-[4-(4-bromophenyl)-1H-imidazol-2-yl]-1,2,3,4-tetrahydroisoquinoline, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total) |
機能のキーワード | p38 kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm (By similarity): Q16539 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 40918.54 |
構造登録者 | |
主引用文献 | Tecle, H.,Feru, F.,Liu, H.,Kuhn, C.,Rennie, G.,Morris, M.,Shao, J.,Cheng, A.C.,Gikunju, D.,Miret, J.,Coli, R.,Xi, S.H.,Clugston, S.L.,Low, S.,Kazmirski, S.,Ding, Y.H.,Cao, Q.,Johnson, T.L.,Deshmukh, G.D.,DiNitto, J.P.,Wu, J.C.,English, J.M. The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay. Chem.Biol.Drug Des., 74:547-559, 2009 Cited by PubMed: 19843080DOI: 10.1111/j.1747-0285.2009.00884.x 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
構造検証レポート
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