3K3E

Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691

Summary for 3K3E

• Entry DOI: 10.2210/pdb3k3e/pdb
• Related: 3K3H
• Descriptor: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde9, catalytic domain, cgmp, hydrolase, manganese, metal-binding, phosphoprotein
• Biological source: Homo sapiens (human)
• Cellular location: Isoform PDE9A1: Cell projection, ruffle membrane. Isoform PDE9A2: Cell projection, ruffle membrane. Isoform PDE9A3: Cytoplasm. Isoform PDE9A17: Cytoplasm: O76083
• Total number of polymer chains: 2
• Total formula weight: 77986.03

Authors

Wang, H.,Luo, X.,Ye, M.,Hou, J.,Robinson, H.,Ke, H. (deposition date: 2009-10-02, release date: 2010-02-16, Last modification date: 2013-11-13)

• Primary citation: Wang, H.,Luo, X.,Ye, M.,Hou, J.,Robinson, H.,Ke, H.; Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis; J.Med.Chem., 53:1726-1731, 2010; PubMed: 20121115; DOI: 10.1021/jm901519f

Experimental method

X-RAY DIFFRACTION (2.7 Å)