3K3E

Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691

3K3E の概要

• エントリーDOI: 10.2210/pdb3k3e/pdb
• 関連するPDBエントリー: 3K3H
• 分子名称: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pde9, catalytic domain, cgmp, hydrolase, manganese, metal-binding, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform PDE9A1: Cell projection, ruffle membrane. Isoform PDE9A2: Cell projection, ruffle membrane. Isoform PDE9A3: Cytoplasm. Isoform PDE9A17: Cytoplasm: O76083
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77986.03

構造登録者

Wang, H.,Luo, X.,Ye, M.,Hou, J.,Robinson, H.,Ke, H. (登録日: 2009-10-02, 公開日: 2010-02-16, 最終更新日: 2013-11-13)

• 主引用文献: Wang, H.,Luo, X.,Ye, M.,Hou, J.,Robinson, H.,Ke, H.; Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis; J.Med.Chem., 53:1726-1731, 2010; PubMed: 20121115; DOI: 10.1021/jm901519f

実験手法

X-RAY DIFFRACTION (2.7 Å)