3K2M
Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex
Summary for 3K2M
Entry DOI | 10.2210/pdb3k2m/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase ABL1, Monobody HA4, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, atp-binding, phosphoprotein, tyrosine-protein kinase, signaling protein, signaling protein-protein binding complex, signaling protein/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 4 |
Total formula weight | 47015.66 |
Authors | Wojcik, J.B.,Duguid, E. (deposition date: 2009-09-30, release date: 2010-03-31, Last modification date: 2023-09-06) |
Primary citation | Wojcik, J.,Hantschel, O.,Grebien, F.,Kaupe, I.,Bennett, K.L.,Barkinge, J.,Jones, R.B.,Koide, A.,Superti-Furga, G.,Koide, S. A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17:519-527, 2010 Cited by PubMed: 20357770DOI: 10.1038/nsmb.1793 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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