3K2M

Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex

3K2M の概要

• エントリーDOI: 10.2210/pdb3k2m/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1, Monobody HA4, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, atp-binding, phosphoprotein, tyrosine-protein kinase, signaling protein, signaling protein-protein binding complex, signaling protein/protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 47015.66

構造登録者

Wojcik, J.B.,Duguid, E. (登録日: 2009-09-30, 公開日: 2010-03-31, 最終更新日: 2023-09-06)

• 主引用文献: Wojcik, J.,Hantschel, O.,Grebien, F.,Kaupe, I.,Bennett, K.L.,Barkinge, J.,Jones, R.B.,Koide, A.,Superti-Furga, G.,Koide, S.; A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.; Nat.Struct.Mol.Biol., 17:519-527, 2010; PubMed: 20357770; DOI: 10.1038/nsmb.1793

実験手法

X-RAY DIFFRACTION (1.75 Å)