3K0X

Crystal structure of telomere capping protein Ten1 from Saccharomyces pombe

3K0X の概要

• エントリーDOI: 10.2210/pdb3k0x/pdb
• 関連するPDBエントリー: 3K10
• 分子名称: Protein Ten1, IODIDE ION (3 entities in total)
• 機能のキーワード: beta barrel, ob fold, telomere capping, chromosomal protein, nucleus, telomere, protein binding
• 由来する生物種: Schizosaccharomyces pombe (yeast)
• 細胞内の位置: Nucleus: P0C5Y7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12564.67

構造登録者

Gelinas, A.D.,Reyes, F.E.,Batey, R.T.,Wuttke, D.S. (登録日: 2009-09-25, 公開日: 2009-10-27, 最終更新日: 2024-02-21)

主引用文献

Gelinas, A.D.,Paschini, M.,Reyes, F.E.,Heroux, A.,Batey, R.T.,Lundblad, V.,Wuttke, D.S.
Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Proc.Natl.Acad.Sci.USA, 106:19298-19303, 2009

PubMed Abstract: Telomeres must be capped to preserve chromosomal stability. The conserved Stn1 and Ten1 proteins are required for proper capping of the telomere, although the mechanistic details of how they contribute to telomere maintenance are unclear. Here, we report the crystal structures of the C-terminal domain of the Saccharomyces cerevisiae Stn1 and the Schizosaccharomyces pombe Ten1 proteins. These structures reveal striking similarities to corresponding subunits in the replication protein A complex, further supporting an evolutionary link between telomere maintenance proteins and DNA repair complexes. Our structural and in vivo data of Stn1 identify a new domain that has evolved to support a telomere-specific role in chromosome maintenance. These findings endorse a model of an evolutionarily conserved mechanism of DNA maintenance that has developed as a result of increased chromosomal structural complexity.

PubMed: 19884503
DOI: 10.1073/pnas.0909203106

実験手法

X-RAY DIFFRACTION (1.7 Å)