3JZK
crystal structure of MDM2 with chromenotriazolopyrimidine 1
Summary for 3JZK
Entry DOI | 10.2210/pdb3jzk/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine (3 entities in total) |
Functional Keywords | mdm2, p53, inhibitor, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 1 |
Total formula weight | 11692.27 |
Authors | Huang, X. (deposition date: 2009-09-23, release date: 2009-11-17, Last modification date: 2023-09-06) |
Primary citation | Allen, J.G.,Bourbeau, M.P.,Wohlhieter, G.E.,Bartberger, M.D.,Michelsen, K.,Hungate, R.,Gadwood, R.C.,Gaston, R.D.,Evans, B.,Mann, L.W.,Matison, M.E.,Schneider, S.,Huang, X.,Yu, D.,Andrews, P.S.,Reichelt, A.,Long, A.M.,Yakowec, P.,Yang, E.Y.,Lee, T.A.,Oliner, J.D. Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J.Med.Chem., 52:7044-7053, 2009 Cited by PubMed: 19856920DOI: 10.1021/jm900681h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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