3JZK

crystal structure of MDM2 with chromenotriazolopyrimidine 1

3JZK の概要

• エントリーDOI: 10.2210/pdb3jzk/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine (3 entities in total)
• 機能のキーワード: mdm2, p53, inhibitor, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11692.27

構造登録者

Huang, X. (登録日: 2009-09-23, 公開日: 2009-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Allen, J.G.,Bourbeau, M.P.,Wohlhieter, G.E.,Bartberger, M.D.,Michelsen, K.,Hungate, R.,Gadwood, R.C.,Gaston, R.D.,Evans, B.,Mann, L.W.,Matison, M.E.,Schneider, S.,Huang, X.,Yu, D.,Andrews, P.S.,Reichelt, A.,Long, A.M.,Yakowec, P.,Yang, E.Y.,Lee, T.A.,Oliner, J.D.; Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.; J.Med.Chem., 52:7044-7053, 2009; PubMed: 19856920; DOI: 10.1021/jm900681h

実験手法

X-RAY DIFFRACTION (2.1 Å)