3JXW
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
3JXW の概要
エントリーDOI | 10.2210/pdb3jxw/pdb |
分子名称 | Proto-oncogene serine/threonine-protein kinase Pim-1, 8-[(E)-2-cyclopropylethenyl]-2-[(dimethylamino)methyl][1]benzothieno[3,2-d]pyrimidin-4(3H)-one (2 entities in total) |
機能のキーワード | pim-1, alternative initiation, atp-binding, cell membrane, cytoplasm, kinase, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, serine/threonine-protein kinase, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 34288.94 |
構造登録者 | |
主引用文献 | Tao, Z.F.,Hasvold, L.,Leverson, J.,Han, E.,Guan, R.,Johson, E.F.,Stoll, V.S.,Stewart, K.D.,Stamper, G.,Soni, N. Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors TO BE PUBLISHED, |
実験手法 | X-RAY DIFFRACTION (2.8 Å) |
構造検証レポート
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