3JXW

Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors

3JXW の概要

• エントリーDOI: 10.2210/pdb3jxw/pdb
• 分子名称: Proto-oncogene serine/threonine-protein kinase Pim-1, 8-[(E)-2-cyclopropylethenyl]-2-[(dimethylamino)methyl][1]benzothieno[3,2-d]pyrimidin-4(3H)-one (2 entities in total)
• 機能のキーワード: pim-1, alternative initiation, atp-binding, cell membrane, cytoplasm, kinase, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34288.94

構造登録者

Stoll, V.S. (登録日: 2009-09-21, 公開日: 2009-11-10, 最終更新日: 2024-02-21)

• 主引用文献: Tao, Z.F.,Hasvold, L.,Leverson, J.,Han, E.,Guan, R.,Johson, E.F.,Stoll, V.S.,Stewart, K.D.,Stamper, G.,Soni, N.; Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors; TO BE PUBLISHED,

実験手法

X-RAY DIFFRACTION (2.8 Å)