3JW1
Crystal Structure of Bovine Pancreatic Ribonuclease Complexed with Uridine-5'-monophosphate at 1.60 A Resolution
Summary for 3JW1
| Entry DOI | 10.2210/pdb3jw1/pdb |
| Descriptor | Ribonuclease pancreatic, URIDINE-5'-MONOPHOSPHATE (3 entities in total) |
| Functional Keywords | ribonuclease a, uridine-5'-monophosphate, structural genomics, psi-2, protein structure initiative, center for high-throughput structural biology, chtsb, endonuclease, glycation, glycoprotein, hydrolase, nuclease, secreted |
| Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
| Cellular location | Secreted: P61823 |
| Total number of polymer chains | 2 |
| Total formula weight | 28065.01 |
| Authors | Larson, S.B.,Day, J.S.,Nguyen, C.,Cudney, R.,Mcpherson, A.,Center for High-Throughput Structural Biology (CHTSB) (deposition date: 2009-09-17, release date: 2009-10-06, Last modification date: 2024-11-20) |
| Primary citation | Larson, S.B.,Day, J.S.,Nguyen, C.,Cudney, R.,McPherson, A. Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution. Acta Crystallogr.,Sect.F, 66:113-120, 2010 Cited by PubMed Abstract: Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5'-monophosphate (U5P). Solution of the crystal structure revealed that the enzyme was selectively bound to U5P, with the pyrimidine ring of U5P residing in the pyrimidine-binding site at Thr45. The structure was refined to an R factor of 0.197 and an R(free) of 0.253. PubMed: 20124705DOI: 10.1107/S174430910905194X PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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