3JVR

Characterization of the Chk1 allosteric inhibitor binding site

Summary for 3JVR

Entry DOI	10.2210/pdb3jvr/pdb
Related	3JVS
Descriptor	Serine/threonine-protein kinase Chk1, (1S)-1-(1H-benzimidazol-2-yl)ethyl (3,4-dichlorophenyl)carbamate (3 entities in total)
Functional Keywords	protein kinase, atp-binding, cell cycle, cytoplasm, dna damage, dna repair, isopeptide bond, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, ubl conjugation
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	31605.17
Authors	Chen, P. (deposition date: 2009-09-17, release date: 2009-10-06, Last modification date: 2024-02-21)
Primary citation	Vanderpool, D.,Johnson, T.O.,Ping, C.,Bergqvist, S.,Alton, G.,Phonephaly, S.,Rui, E.,Luo, C.,Deng, Y.L.,Grant, S.,Quenzer, T.,Margosiak, S.,Register, J.,Brown, E.,Ermolieff, J. Characterization of the CHK1 allosteric inhibitor binding site. Biochemistry, 48:9823-9830, 2009 Cited by PubMed: 19743875 DOI: 10.1021/bi900258v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation