3JUS

Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole

Summary for 3JUS

Entry DOI	10.2210/pdb3jus/pdb
Related	3I3K 3JUV
Related PRD ID	PRD_900012
Descriptor	Lanosterol 14-alpha demethylase, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, ... (6 entities in total)
Functional Keywords	cytochrome p450, sterol 14alpha-demethylase, econazole, structural genomics, structural genomics consortium, sgc, cholesterol biosynthesis, endoplasmic reticulum, heme, iron, lipid synthesis, membrane, metal-binding, microsome, monooxygenase, nadp, oxidoreductase, steroid biosynthesis, sterol biosynthesis, transmembrane
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	110604.64
Authors	Strushkevich, N.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Usanov, S.A.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-09-15, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citation	Strushkevich, N.,Usanov, S.A.,Park, H.W. Structural basis of human CYP51 inhibition by antifungal azoles. J. Mol. Biol., 397:1067-1078, 2010 Cited by PubMed: 20149798 DOI: 10.1016/j.jmb.2010.01.075 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation