3JUS

Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole

3JUS の概要

• エントリーDOI: 10.2210/pdb3jus/pdb
• 関連するPDBエントリー: 3I3K 3JUV
• 関連するBIRD辞書のPRD_ID: PRD_900012
• 分子名称: Lanosterol 14-alpha demethylase, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, ... (6 entities in total)
• 機能のキーワード: cytochrome p450, sterol 14alpha-demethylase, econazole, structural genomics, structural genomics consortium, sgc, cholesterol biosynthesis, endoplasmic reticulum, heme, iron, lipid synthesis, membrane, metal-binding, microsome, monooxygenase, nadp, oxidoreductase, steroid biosynthesis, sterol biosynthesis, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110604.64

構造登録者

Strushkevich, N.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Usanov, S.A.,Park, H.,Structural Genomics Consortium (SGC) (登録日: 2009-09-15, 公開日: 2010-03-02, 最終更新日: 2023-09-06)

• 主引用文献: Strushkevich, N.,Usanov, S.A.,Park, H.W.; Structural basis of human CYP51 inhibition by antifungal azoles.; J. Mol. Biol., 397:1067-1078, 2010; PubMed: 20149798; DOI: 10.1016/j.jmb.2010.01.075

実験手法

X-RAY DIFFRACTION (2.9 Å)