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3JT9

Structure of neuronal nitric oxide synthase heme domain in the ferrous state complexed with N~5~-[2-(ethylsulfanyl)ethanimidoyl]-L-ornithine

3JT9 の概要
エントリーDOI10.2210/pdb3jt9/pdb
関連するPDBエントリー3JT3 3JT4 3JT5 3JT6 3JT7 3JT8 3JTA
分子名称Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
機能のキーワードnitric oxide synthase, heme-thiolate enzyme, substrate-analogue inhibitor, thioether heme ligand, alternative splicing, calmodulin-binding, cell membrane, cell projection, fad, fmn, heme, iron, membrane, metal-binding, nadp, oxidoreductase
由来する生物種Rattus norvegicus
タンパク質・核酸の鎖数2
化学式量合計99990.68
構造登録者
Li, H.,Poulos, T.L. (登録日: 2009-09-11, 公開日: 2010-01-12, 最終更新日: 2023-09-06)
主引用文献Martell, J.D.,Li, H.,Doukov, T.,Martasek, P.,Roman, L.J.,Soltis, M.,Poulos, T.L.,Silverman, R.B.
Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132:798-806, 2010
Cited by
PubMed: 20014790
DOI: 10.1021/ja908544f
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.1 Å)
構造検証レポート
Validation report summary of 3jt9
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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