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3JT7

Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[2-(propylsulfanyl)ethanimidoyl]-L-ornithine

Summary for 3JT7
Entry DOI10.2210/pdb3jt7/pdb
Related3JT3 3JT4 3JT5 3JT6 3JT8 3JT9 3JTA
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, heme-thiolate enzyme, substrate-analogue inhibitor, thioether heme ligand, alternative splicing, calmodulin-binding, cell membrane, cell projection, fad, fmn, heme, iron, membrane, metal-binding, nadp, oxidoreductase
Biological sourceRattus norvegicus
Total number of polymer chains2
Total formula weight100018.74
Authors
Li, H.,Poulos, T.L. (deposition date: 2009-09-11, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citationMartell, J.D.,Li, H.,Doukov, T.,Martasek, P.,Roman, L.J.,Soltis, M.,Poulos, T.L.,Silverman, R.B.
Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132:798-806, 2010
Cited by
PubMed: 20014790
DOI: 10.1021/ja908544f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

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