3JT4
Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[(3-(ethylsulfanyl)propanimidoyl]-L-ornithine
3JT4 の概要
エントリーDOI | 10.2210/pdb3jt4/pdb |
関連するPDBエントリー | 3JT3 3JT5 3JT6 3JT7 3JT8 3JT9 3JTA |
分子名称 | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
機能のキーワード | nitric oxide synthase, heme-thiolate enzyme, substrate-analogue inhibitor, thioether heme ligand, alternative splicing, calmodulin-binding, cell membrane, cell projection, fad, fmn, heme, iron, membrane, metal-binding, nadp, oxidoreductase |
由来する生物種 | Rattus norvegicus (brown rat,rat,rats) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 100018.74 |
構造登録者 | |
主引用文献 | Martell, J.D.,Li, H.,Doukov, T.,Martasek, P.,Roman, L.J.,Soltis, M.,Poulos, T.L.,Silverman, R.B. Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. J.Am.Chem.Soc., 132:798-806, 2010 Cited by PubMed: 20014790DOI: 10.1021/ja908544f 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード