3JS3

Crystal structure of type I 3-dehydroquinate dehydratase (aroD) from Clostridium difficile with covalent reaction intermediate

Summary for 3JS3

• Entry DOI: 10.2210/pdb3js3/pdb
• Descriptor: 3-dehydroquinate dehydratase, 3-AMINO-4,5-DIHYDROXY-CYCLOHEX-1-ENECARBOXYLATE (3 entities in total)
• Functional Keywords: type i 3-dehydroquinate dehydratase, arod, covalent reaction intermediate, amino-acid biosynthesis, aromatic amino acid biosynthesis, lyase, schiff base, structural genomics, center for structural genomics of infectious diseases, csgid
• Biological source: Clostridium difficile
• Total number of polymer chains: 4
• Total formula weight: 117440.86

Authors

Minasov, G.,Light, S.H.,Shuvalova, L.,Dubrovska, I.,Winsor, J.,Peterson, S.N.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2009-09-09, release date: 2009-09-22, Last modification date: 2023-09-06)

• Primary citation: Light, S.H.,Minasov, G.,Shuvalova, L.,Duban, M.E.,Caffrey, M.,Anderson, W.F.,Lavie, A.; Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.; J.Biol.Chem., 286:3531-3539, 2011; PubMed: 21087925; DOI: 10.1074/jbc.M110.192831

Experimental method

X-RAY DIFFRACTION (2.2 Å)