3J63

Unified assembly mechanism of ASC-dependent inflammasomes

Summary for 3J63

Entry DOI	10.2210/pdb3j63/pdb
EMDB information	5830
Descriptor	Apoptosis-associated speck-like protein containing a CARD (1 entity in total)
Functional Keywords	helical polymer, variable twist, death domain, apoptosis
Biological source	Homo sapiens (human)
Total number of polymer chains	15
Total formula weight	151374.98
Authors	Lu, A.,Magupalli, V.G.,Ruan, J.,Yin, Q.,Atianand, M.K.,Vos, M.,Schroder, G.F.,Fitzgerald, K.A.,Wu, H.,Egelman, E.H. (deposition date: 2013-12-05, release date: 2014-03-26, Last modification date: 2024-02-21)
Primary citation	Lu, A.,Magupalli, V.G.,Ruan, J.,Yin, Q.,Atianand, M.K.,Vos, M.R.,Schroder, G.F.,Fitzgerald, K.A.,Wu, H.,Egelman, E.H. Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes. Cell(Cambridge,Mass.), 156:1193-1206, 2014 Cited by PubMed: 24630722 DOI: 10.1016/j.cell.2014.02.008 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation