3IXJ

Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor

3IXJ の概要

• エントリーDOI: 10.2210/pdb3ixj/pdb
• 分子名称: Beta-secretase 1, N-[4-(1-BENZYLCARBAMOYL-2-METHYL-PROPYLCARBAMOYL)-1-(3,5-DIFLUORO-PHENOXYMETHYL)-2-HYDROXY-4-METHOXY-BUTYL]-5-(METHANESULFONYL-METHYL-AMINO)-N'-(1-PHENYLETHYL)-ISOPHTHALAMIDE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: bace, beta secretase-1, inhibitor, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen, disulfide bond, polymorphism, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 132611.32

構造登録者

Borkakoti, N.,Lindberg, J.,Nystrom, S. (登録日: 2009-09-04, 公開日: 2010-03-02, 最終更新日: 2011-07-13)

• 主引用文献: Bjorklund, C.,Oscarson, S.,Benkestock, K.,Borkakoti, N.,Jansson, K.,Lindberg, J.,Vrang, L.,Hallberg, A.,Rosenquist, A.,Samuelsson, B.; Design and Synthesis of Potent and Selective BACE-1 Inhibitors.; J.Med.Chem., 53:1458-1464, 2010; PubMed: 20128595; DOI: 10.1021/jm901168f

実験手法

X-RAY DIFFRACTION (2.2 Å)