3IWX

Crystal structure of cisplatin bound to a human copper chaperone (dimer)

3IWX の概要

• エントリーDOI: 10.2210/pdb3iwx/pdb
• 関連するPDBエントリー: 3IWL
• 分子名称: Copper transport protein ATOX1, Cisplatin, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: beta-alpha-beta-beta-alpha-beta, transport protein, cisplatin, platinum, chaperone, copper transport, ion transport, metal-binding, transport, metal transport
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 15413.53

構造登録者

Boal, A.K.,Rosenzweig, A.C. (登録日: 2009-09-03, 公開日: 2009-09-22, 最終更新日: 2024-02-21)

主引用文献

Boal, A.K.,Rosenzweig, A.C.
Crystal structures of cisplatin bound to a human copper chaperone.
J.Am.Chem.Soc., 131:14196-14197, 2009

PubMed Abstract: Copper trafficking proteins, including the chaperone Atox1 and the P(1B)-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.

PubMed: 19807176
DOI: 10.1021/ja906363t

実験手法

X-RAY DIFFRACTION (2.14 Å)