3IRX
Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.
3IRX の概要
エントリーDOI | 10.2210/pdb3irx/pdb |
関連するPDBエントリー | 3IS9 |
分子名称 | Reverse transcriptase/ribonuclease H, Reverse transcriptase, (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methy lbenzothioate (3 entities in total) |
機能のキーワード | nnrti, nonnucleoside inhibitor, aids, hiv, p51/p66, adam, aspartyl protease, cell membrane, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger, transferase-hydrolase complex, transferase/hydrolase |
由来する生物種 | Human immunodeficiency virus type 1 BH10 (HIV-1) 詳細 |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114593.38 |
構造登録者 | |
主引用文献 | Cullen, M.D.,Ho, W.C.,Bauman, J.D.,Das, K.,Arnold, E.,Hartman, T.L.,Watson, K.M.,Buckheit, R.W.,Pannecouque, C.,De Clercq, E.,Cushman, M. Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate. J.Med.Chem., 52:6467-6473, 2009 Cited by PubMed: 19775161DOI: 10.1021/jm901167t 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.8 Å) |
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