3IQA

Crystal Structure of BlaC covalently bound with Doripenem

Summary for 3IQA

• Entry DOI: 10.2210/pdb3iqa/pdb
• Descriptor: Beta-lactamase, PHOSPHATE ION, (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ... (4 entities in total)
• Functional Keywords: penicillin binding protein, beta-lactam covalent adduct, antibiotic resistance, cell membrane, hydrolase, lipoprotein, membrane, palmitate, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 28885.18

Authors

Tremblay, L.W.,Blanchard, J.S. (deposition date: 2009-08-19, release date: 2010-04-14, Last modification date: 2023-09-06)

• Primary citation: Tremblay, L.W.,Fan, F.,Blanchard, J.S.; Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.; Biochemistry, 49:3766-3773, 2010; PubMed: 20353175; DOI: 10.1021/bi100232q

Experimental method

X-RAY DIFFRACTION (2.2 Å)