3IQ7
Crystal Structure of human Haspin in complex with 5-Iodotubercidin
Summary for 3IQ7
Entry DOI | 10.2210/pdb3iq7/pdb |
Descriptor | Serine/threonine-protein kinase haspin, PHOSPHATE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (6 entities in total) |
Functional Keywords | haspin, germ cell associated 2, haploid germ cell specific nuclear protein kinase, sgc, structural genomics consortium, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q8TF76 |
Total number of polymer chains | 1 |
Total formula weight | 41449.64 |
Authors | Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-08-19, release date: 2009-09-08, Last modification date: 2023-11-01) |
Primary citation | Eswaran, J.,Patnaik, D.,Filippakopoulos, P.,Wang, F.,Stein, R.L.,Murray, J.W.,Higgins, J.M.,Knapp, S. Structure and functional characterization of the atypical human kinase haspin. Proc.Natl.Acad.Sci.USA, 106:20198-20203, 2009 Cited by PubMed: 19918057DOI: 10.1073/pnas.0901989106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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