3IQ7

Crystal Structure of human Haspin in complex with 5-Iodotubercidin

3IQ7 の概要

• エントリーDOI: 10.2210/pdb3iq7/pdb
• 分子名称: Serine/threonine-protein kinase haspin, PHOSPHATE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (6 entities in total)
• 機能のキーワード: haspin, germ cell associated 2, haploid germ cell specific nuclear protein kinase, sgc, structural genomics consortium, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q8TF76
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41449.64

構造登録者

Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-08-19, 公開日: 2009-09-08, 最終更新日: 2023-11-01)

• 主引用文献: Eswaran, J.,Patnaik, D.,Filippakopoulos, P.,Wang, F.,Stein, R.L.,Murray, J.W.,Higgins, J.M.,Knapp, S.; Structure and functional characterization of the atypical human kinase haspin.; Proc.Natl.Acad.Sci.USA, 106:20198-20203, 2009; PubMed: 19918057; DOI: 10.1073/pnas.0901989106

実験手法

X-RAY DIFFRACTION (2 Å)