3IKK

Crystal structure analysis of msp domain

Summary for 3IKK

Entry DOI	10.2210/pdb3ikk/pdb
Descriptor	Vesicle-associated membrane protein-associated protein B/C (2 entities in total)
Functional Keywords	vapb msp, alternative splicing, amyotrophic lateral sclerosis, cell membrane, coiled coil, disease mutation, host-virus interaction, membrane, neurodegeneration, phosphoprotein, transmembrane, membrane protein
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity): O95292
Total number of polymer chains	2
Total formula weight	28720.98
Authors	Shi, J.,Lua, S.,Song, J. (deposition date: 2009-08-06, release date: 2010-05-26, Last modification date: 2023-11-01)
Primary citation	Shi, J.,Lua, S.,Tong, J.S.,Song, J. Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis. Biochemistry, 49:3887-3897, 2010 Cited by PubMed: 20377183 DOI: 10.1021/bi902057a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation