3IKK

Crystal structure analysis of msp domain

3IKK の概要

• エントリーDOI: 10.2210/pdb3ikk/pdb
• 分子名称: Vesicle-associated membrane protein-associated protein B/C (2 entities in total)
• 機能のキーワード: vapb msp, alternative splicing, amyotrophic lateral sclerosis, cell membrane, coiled coil, disease mutation, host-virus interaction, membrane, neurodegeneration, phosphoprotein, transmembrane, membrane protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity): O95292
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28720.98

構造登録者

Shi, J.,Lua, S.,Song, J. (登録日: 2009-08-06, 公開日: 2010-05-26, 最終更新日: 2023-11-01)

• 主引用文献: Shi, J.,Lua, S.,Tong, J.S.,Song, J.; Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis.; Biochemistry, 49:3887-3897, 2010; PubMed: 20377183; DOI: 10.1021/bi902057a

実験手法

X-RAY DIFFRACTION (2.5 Å)