3IJT

Structural Characterization of SMU.440, a Hypothetical Protein from Streptococcus mutans

「2B79」から置き換えられました

3IJT の概要

• エントリーDOI: 10.2210/pdb3ijt/pdb
• 分子名称: Putative uncharacterized protein (2 entities in total)
• 機能のキーワード: hypothetical protein, unknown function
• 由来する生物種: Streptococcus mutans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34853.00

構造登録者

Nan, J.,Brostromer, E.,Kristensen, O.,Su, X.-D. (登録日: 2009-08-05, 公開日: 2009-08-25, 最終更新日: 2024-03-20)

主引用文献

Nan, J.,Brostromer, E.,Liu, X.-Y.,Kristensen, O.,Su, X.-D.
Bioinformatics and structural characterization of a hypothetical protein from Streptococcus mutans: implication of antibiotic resistance
Plos One, 4:e7245-e7245, 2009

PubMed Abstract: As an oral bacterial pathogen, Streptococcus mutans has been known as the aetiologic agent of human dental caries. Among a total of 1960 identified proteins within the genome of this organism, there are about 500 without any known functions. One of these proteins, SMU.440, has very few homologs in the current protein databases and it does not fall into any protein functional families. Phylogenetic studies showed that SMU.440 is related to a particular ecological niche and conserved specifically in some oral pathogens, due to lateral gene transfer. The co-occurrence of a MarR protein within the same operon among these oral pathogens suggests that SMU.440 may be associated with antibiotic resistance. The structure determination of SMU.440 revealed that it shares the same fold and a similar pocket as polyketide cyclases, which indicated that it is very likely to bind some polyketide-like molecules. From the interlinking structural and bioinformatics studies, we have concluded that SMU.440 could be involved in polyketide-like antibiotic resistance, providing a better understanding of this hypothetical protein. Besides, the combination of multiple methods in this study can be used as a general approach for functional studies of a protein with unknown function.

PubMed: 19798411
DOI: 10.1371/journal.pone.0007245

実験手法

X-RAY DIFFRACTION (2.377 Å)