3IJ7
Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase
3IJ7 の概要
エントリーDOI | 10.2210/pdb3ij7/pdb |
関連するPDBエントリー | 3IJ8 3IJ9 |
分子名称 | Pancreatic alpha-amylase, 4-O-methyl-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-2)-5-fluoro-alpha-L-idopyranose, 4-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranosyl fluoride, ... (6 entities in total) |
機能のキーワード | amylase, covalent intermediate, hydrolytic cleavage, catalysis, inhibitor synthesis, enzyme kinetics, human digestion, diabetes, obesity, carbohydrate metabolism, chloride, disulfide bond, glycoprotein, glycosidase, hydrolase, metal-binding, pyrrolidone carboxylic acid, secreted |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 56901.60 |
構造登録者 | |
主引用文献 | Zhang, R.,Li, C.,Williams, L.K.,Rempel, B.P.,Brayer, G.D.,Withers, S.G. Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48:10752-10764, 2009 Cited by PubMed: 19803533DOI: 10.1021/bi901400p 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード