3IGB
Bace-1 with Compound 3
Summary for 3IGB
Entry DOI | 10.2210/pdb3igb/pdb |
Descriptor | Beta-secretase 1, 8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (3 entities in total) |
Functional Keywords | bace-1, amino-imidazoles, inhibitors, alternative splicing, aspartyl protease, disulfide bond, glycoprotein, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 46731.34 |
Authors | Olland, A.M. (deposition date: 2009-07-27, release date: 2009-11-03, Last modification date: 2023-09-06) |
Primary citation | Malamas, M.S.,Erdei, J.,Gunawan, I.,Barnes, K.,Johnson, M.,Hui, Y.,Turner, J.,Hu, Y.,Wagner, E.,Fan, K.,Olland, A.,Bard, J.,Robichaud, A.J. Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors J.Med.Chem., 52:6314-6323, 2009 Cited by PubMed: 19757823DOI: 10.1021/jm9006752 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.238 Å) |
Structure validation
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