3IGB

Bace-1 with Compound 3

3IGB の概要

• エントリーDOI: 10.2210/pdb3igb/pdb
• 分子名称: Beta-secretase 1, 8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (3 entities in total)
• 機能のキーワード: bace-1, amino-imidazoles, inhibitors, alternative splicing, aspartyl protease, disulfide bond, glycoprotein, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46731.34

構造登録者

Olland, A.M. (登録日: 2009-07-27, 公開日: 2009-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Malamas, M.S.,Erdei, J.,Gunawan, I.,Barnes, K.,Johnson, M.,Hui, Y.,Turner, J.,Hu, Y.,Wagner, E.,Fan, K.,Olland, A.,Bard, J.,Robichaud, A.J.; Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors; J.Med.Chem., 52:6314-6323, 2009; PubMed: 19757823; DOI: 10.1021/jm9006752

実験手法

X-RAY DIFFRACTION (2.238 Å)