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3IG1

HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site

3IG1 の概要
エントリーDOI10.2210/pdb3ig1/pdb
分子名称HIV-1 Reverse Transcriptase p66 subunit, HIV-1 Reverse Transcriptase p51 subunit, 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, ... (5 entities in total)
機能のキーワードrnase h inhibitor, protein-inhibitor complex, structure-based drug design, tropolones, tropylium ion, divalent cation chelator, aids, dna-directed dna polymerase, metal-binding, multifunctional enzyme, nucleotidyltransferase, rna-binding, rna-directed dna polymerase, transferase
由来する生物種Human immunodeficiency virus type 1 BH10 (HIV-1)
詳細
細胞内の位置Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
タンパク質・核酸の鎖数2
化学式量合計114144.58
構造登録者
Himmel, D.M.,Maegley, K.A.,Pauly, T.A.,Arnold, E. (登録日: 2009-07-27, 公開日: 2010-01-26, 最終更新日: 2023-09-06)
主引用文献Himmel, D.M.,Maegley, K.A.,Pauly, T.A.,Bauman, J.D.,Das, K.,Dharia, C.,Clark, A.D.,Ryan, K.,Hickey, M.J.,Love, R.A.,Hughes, S.H.,Bergqvist, S.,Arnold, E.
Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
Structure, 17:1625-1635, 2009
Cited by
PubMed: 20004166
DOI: 10.1016/j.str.2009.09.016
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.8 Å)
構造検証レポート
Validation report summary of 3ig1
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-09-11に公開中

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