3IFP
X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex
Summary for 3IFP
Entry DOI | 10.2210/pdb3ifp/pdb |
Related | 3IFL 3IFN 3IFO |
Descriptor | 12B4 FAB antibody heavy chain, 12B4 FAB antibody light chain, Amyloid beta A4 protein (3 entities in total) |
Functional Keywords | antibody, amyloid beta peptide, immune system |
Biological source | Mus musculus (mouse) More |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 12 |
Total formula weight | 198621.06 |
Authors | Weis, W.I.,Feinberg, H.,Basi, G.S.,Schenk, D. (deposition date: 2009-07-24, release date: 2009-11-17, Last modification date: 2013-09-25) |
Primary citation | Basi, G.S.,Feinberg, H.,Oshidari, F.,Anderson, J.,Barbour, R.,Baker, J.,Comery, T.A.,Diep, L.,Gill, D.,Johnson-Wood, K.,Goel, A.,Grantcharova, K.,Lee, M.,Li, J.,Partridge, A.,Griswold-Prenner, I.,Piot, N.,Walker, D.,Widom, A.,Pangalos, M.N.,Seubert, P.,Jacobsen, J.S.,Schenk, D.,Weis, W.I. Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J.Biol.Chem., 285:3417-3427, 2010 Cited by PubMed: 19923222DOI: 10.1074/jbc.M109.045187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
Download full validation report