3IFN

X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex

3IFN の概要

• エントリーDOI: 10.2210/pdb3ifn/pdb
• 関連するPDBエントリー: 3IFL 3IFO 3IFP
• 分子名称: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein, ... (4 entities in total)
• 機能のキーワード: antibody, amyloid beta peptide, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: 3IFN
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 52405.49

構造登録者

Weis, W.I.,Feinberg, H.,Basi, G.S.,Schenk, D. (登録日: 2009-07-24, 公開日: 2009-11-17, 最終更新日: 2013-06-19)

• 主引用文献: Basi, G.S.,Feinberg, H.,Oshidari, F.,Anderson, J.,Barbour, R.,Baker, J.,Comery, T.A.,Diep, L.,Gill, D.,Johnson-Wood, K.,Goel, A.,Grantcharova, K.,Lee, M.,Li, J.,Partridge, A.,Griswold-Prenner, I.,Piot, N.,Walker, D.,Widom, A.,Pangalos, M.N.,Seubert, P.,Jacobsen, J.S.,Schenk, D.,Weis, W.I.; Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.; J.Biol.Chem., 285:3417-3427, 2010; PubMed: 19923222; DOI: 10.1074/jbc.M109.045187

実験手法

X-RAY DIFFRACTION (1.5 Å)