3IBI
The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
3IBI の概要
エントリーDOI | 10.2210/pdb3ibi/pdb |
関連するPDBエントリー | 1CA2 3IBL 3IBN 3IBU |
分子名称 | Carbonic anhydrase 2, ZINC ION, octyl sulfamate, ... (6 entities in total) |
機能のキーワード | carbonic anhydrase ii, protein-inhibitor complex, aliphatic sulfamate inhibitor, disease mutation, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P00918 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 29806.74 |
構造登録者 | |
主引用文献 | Vitale, R.M.,Alterio, V.,Innocenti, A.,Winum, J.-Y.,Monti, S.M.,De Simone, G.,Supuran, C.T. Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors J.Med.Chem., 52:5990-5998, 2009 Cited by PubMed: 19731956DOI: 10.1021/jm900641r 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.93 Å) |
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