3IBI

The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor

3IBI の概要

• エントリーDOI: 10.2210/pdb3ibi/pdb
• 関連するPDBエントリー: 1CA2 3IBL 3IBN 3IBU
• 分子名称: Carbonic anhydrase 2, ZINC ION, octyl sulfamate, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase ii, protein-inhibitor complex, aliphatic sulfamate inhibitor, disease mutation, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29806.74

構造登録者

Alterio, V.,De Simone, G. (登録日: 2009-07-16, 公開日: 2009-09-22, 最終更新日: 2023-11-01)

• 主引用文献: Vitale, R.M.,Alterio, V.,Innocenti, A.,Winum, J.-Y.,Monti, S.M.,De Simone, G.,Supuran, C.T.; Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors; J.Med.Chem., 52:5990-5998, 2009; PubMed: 19731956; DOI: 10.1021/jm900641r

実験手法

X-RAY DIFFRACTION (1.93 Å)