3IBE
Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma
Summary for 3IBE
Entry DOI | 10.2210/pdb3ibe/pdb |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, ... (4 entities in total) |
Functional Keywords | pi3kinase inhibitor, atp-binding, kinase, nucleotide-binding, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 111456.89 |
Authors | Bard, J.,Svenson, K. (deposition date: 2009-07-15, release date: 2009-09-01, Last modification date: 2023-09-06) |
Primary citation | Zask, A.,Verheijen, J.C.,Curran, K.,Kaplan, J.,Richard, D.J.,Nowak, P.,Malwitz, D.J.,Brooijmans, N.,Bard, J.,Svenson, K.,Lucas, J.,Toral-Barza, L.,Zhang, W.G.,Hollander, I.,Gibbons, J.J.,Abraham, R.T.,Ayral-Kaloustian, S.,Mansour, T.S.,Yu, K. ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines. J.Med.Chem., 52:5013-5016, 2009 Cited by PubMed: 19645448DOI: 10.1021/jm900851f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.798 Å) |
Structure validation
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