3IBE

Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma

3IBE の概要

• エントリーDOI: 10.2210/pdb3ibe/pdb
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, ... (4 entities in total)
• 機能のキーワード: pi3kinase inhibitor, atp-binding, kinase, nucleotide-binding, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111456.89

構造登録者

Bard, J.,Svenson, K. (登録日: 2009-07-15, 公開日: 2009-09-01, 最終更新日: 2023-09-06)

• 主引用文献: Zask, A.,Verheijen, J.C.,Curran, K.,Kaplan, J.,Richard, D.J.,Nowak, P.,Malwitz, D.J.,Brooijmans, N.,Bard, J.,Svenson, K.,Lucas, J.,Toral-Barza, L.,Zhang, W.G.,Hollander, I.,Gibbons, J.J.,Abraham, R.T.,Ayral-Kaloustian, S.,Mansour, T.S.,Yu, K.; ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.; J.Med.Chem., 52:5013-5016, 2009; PubMed: 19645448; DOI: 10.1021/jm900851f

実験手法

X-RAY DIFFRACTION (2.798 Å)