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3I7E

Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038

Summary for 3I7E
Entry DOI10.2210/pdb3i7e/pdb
DescriptorHIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE (3 entities in total)
Functional Keywordsaids, hiv, hiv prtease, hiv-protease inhibitor, drug design, aspartic protease, acid protease, structure based drug design, aspartyl protease, hydrolase, protease
Biological sourceHuman immunodeficiency virus 1 (HIV-1)
Total number of polymer chains2
Total formula weight22166.20
Authors
Hong, L.,Tang, J.,Ghosh, A. (deposition date: 2009-07-08, release date: 2009-09-29, Last modification date: 2024-02-21)
Primary citationGhosh, A.K.,Kulkarni, S.,Anderson, D.D.,Hong, L.,Baldridge, A.,Wang, Y.F.,Chumanevich, A.A.,Kovalevsky, A.Y.,Tojo, Y.,Amano, M.,Koh, Y.,Tang, J.,Weber, I.T.,Mitsuya, H.
Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance.
J.Med.Chem., 52:7689-7705, 2009
Cited by
PubMed: 19746963
DOI: 10.1021/jm900695w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

건을2024-03-27부터공개중

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