3I7E
Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038
3I7E の概要
エントリーDOI | 10.2210/pdb3i7e/pdb |
分子名称 | HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE (3 entities in total) |
機能のキーワード | aids, hiv, hiv prtease, hiv-protease inhibitor, drug design, aspartic protease, acid protease, structure based drug design, aspartyl protease, hydrolase, protease |
由来する生物種 | Human immunodeficiency virus 1 (HIV-1) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22166.20 |
構造登録者 | |
主引用文献 | Ghosh, A.K.,Kulkarni, S.,Anderson, D.D.,Hong, L.,Baldridge, A.,Wang, Y.F.,Chumanevich, A.A.,Kovalevsky, A.Y.,Tojo, Y.,Amano, M.,Koh, Y.,Tang, J.,Weber, I.T.,Mitsuya, H. Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance. J.Med.Chem., 52:7689-7705, 2009 Cited by PubMed: 19746963DOI: 10.1021/jm900695w 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード