3I7E

Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038

3I7E の概要

• エントリーDOI: 10.2210/pdb3i7e/pdb
• 分子名称: HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE (3 entities in total)
• 機能のキーワード: aids, hiv, hiv prtease, hiv-protease inhibitor, drug design, aspartic protease, acid protease, structure based drug design, aspartyl protease, hydrolase, protease
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22166.20

構造登録者

Hong, L.,Tang, J.,Ghosh, A. (登録日: 2009-07-08, 公開日: 2009-09-29, 最終更新日: 2024-02-21)

• 主引用文献: Ghosh, A.K.,Kulkarni, S.,Anderson, D.D.,Hong, L.,Baldridge, A.,Wang, Y.F.,Chumanevich, A.A.,Kovalevsky, A.Y.,Tojo, Y.,Amano, M.,Koh, Y.,Tang, J.,Weber, I.T.,Mitsuya, H.; Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance.; J.Med.Chem., 52:7689-7705, 2009; PubMed: 19746963; DOI: 10.1021/jm900695w

実験手法

X-RAY DIFFRACTION (1.7 Å)