3I4O

Crystal Structure of Translation Initiation Factor 1 from Mycobacterium tuberculosis

3I4O の概要

• エントリーDOI: 10.2210/pdb3i4o/pdb
• 分子名称: Translation initiation factor IF-1 (2 entities in total)
• 機能のキーワード: translation initiation, if1, initiation factor, protein biosynthesis, translation
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 18271.29

構造登録者

Hatzopoulos, G.N.,Mueller-Dieckmann, J. (登録日: 2009-07-02, 公開日: 2010-02-23, 最終更新日: 2024-03-20)

主引用文献

Hatzopoulos, G.N.,Mueller-Dieckmann, J.
Structure of translation initiation factor 1 from Mycobacterium tuberculosis and inferred binding to the 30S ribosomal subunit.
Febs Lett., 584:1011-1015, 2010

PubMed Abstract: The crystal structure of the free form of IF1 from Mycobacterium tuberculosis has been determined at 1.47 A resolution. The structure adopts the expected OB fold and matches the high structural conservation among IF1 orthologues. In order to further explore the function of Mtb-IF1, we built a model of its interaction with the 30S ribosomal subunit based on the crystal structure of the complex from Thermus thermophilus. The model suggests that several functionally important side chain residues undergo large movements while the rest of the protein in complex shows only very limited conformational change as compared to its form in solution.

PubMed: 20132820
DOI: 10.1016/j.febslet.2010.01.051

実験手法

X-RAY DIFFRACTION (1.47 Å)