3I4B

Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor

3I4B の概要

• エントリーDOI: 10.2210/pdb3i4b/pdb
• 分子名称: Glycogen synthase kinase-3 beta, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide (3 entities in total)
• 機能のキーワード: kinase, gsk3b, erk, pyrimidyl pyrrole, alternative splicing, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P49841
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93055.73

構造登録者

Ter Haar, E. (登録日: 2009-07-01, 公開日: 2010-01-12, 最終更新日: 2024-04-03)

主引用文献

Aronov, A.M.,Tang, Q.,Martinez-Botella, G.,Bemis, G.W.,Cao, J.,Chen, G.,Ewing, N.P.,Ford, P.J.,Germann, U.A.,Green, J.,Hale, M.R.,Jacobs, M.,Janetka, J.W.,Maltais, F.,Markland, W.,Namchuk, M.N.,Nanthakumar, S.,Poondru, S.,Straub, J.,ter Haar, E.,Xie, X.
Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
J.Med.Chem., 52:6362-6368, 2009

PubMed Abstract: The Ras/Raf/MEK/ERK signal transduction, an oncogenic pathway implicated in a variety of human cancers, is a key target in anticancer drug design. A novel series of pyrimidylpyrrole ERK inhibitors has been identified. Discovery of a conformational change for lead compound 2, when bound to ERK2 relative to antitarget GSK3, enabled structure-guided selectivity optimization, which led to the discovery of 11e, a potent, selective, and orally bioavailable inhibitor of ERK.

PubMed: 19827834
DOI: 10.1021/jm900630q

実験手法

X-RAY DIFFRACTION (2.3 Å)