3HYM

Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure

3HYM の概要

• エントリーDOI: 10.2210/pdb3hym/pdb
• 分子名称: Anaphase-promoting complex subunit CDC26, Cell division cycle protein 16 homolog (3 entities in total)
• 機能のキーワード: apc, anaphase promoting complex, cell cycle, mitosis, cyclosome, tpr, ubiquitin, ubiquitin ligase, e3, twinning, alternative splicing, cell division, phosphoprotein, tpr repeat, ubl conjugation pathway, coiled coil, nucleus, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome: Q8NHZ8; Nucleus (By similarity): Q13042
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 249117.64

構造登録者

Wang, J.,Dye, B.T.,Rajashankar, K.R.,Kurinov, I.,Schulman, B.A. (登録日: 2009-06-22, 公開日: 2009-08-11, 最終更新日: 2024-11-20)

主引用文献

Wang, J.,Dye, B.T.,Rajashankar, K.R.,Kurinov, I.,Schulman, B.A.
Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.
Nat.Struct.Mol.Biol., 16:987-989, 2009

PubMed Abstract: The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein.

PubMed: 19668213
DOI: 10.1038/nsmb.1645

実験手法

X-RAY DIFFRACTION (2.8 Å)