3HTT

The hemagglutinin structure of an avian H1N1 influenza A virus in complex with 2,3-sialyllactose

3HTT の概要

• エントリーDOI: 10.2210/pdb3htt/pdb
• 関連するPDBエントリー: 3HTO 3HTP 3HTQ
• 関連するBIRD辞書のPRD_ID: PRD_900025
• 分子名称: Hemagglutinin, Hemagglutinin HA2 chain, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: receptor, viral protein
• 由来する生物種: Influenza A virus (A/WDK/JX/12416/2005(H1N1)) (A/WDK/JX/12416/2005(H1N1)); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55734.76

構造登録者

Wang, G.,Li, A.,Zhang, Q.,Wu, C.,Zhang, R.,Cai, Q.,Song, W.,Yuen, K.-Y. (登録日: 2009-06-12, 公開日: 2009-08-11, 最終更新日: 2024-11-13)

主引用文献

Lin, T.,Wang, G.,Li, A.,Zhang, Q.,Wu, C.,Zhang, R.,Cai, Q.,Song, W.,Yuen, K.-Y.
The hemagglutinin structure of an avian H1N1 influenza A virus
Virology, 392:73-81, 2009

PubMed Abstract: The interaction between hemagglutinin (HA) and receptors is a kernel in the study of evolution and host adaptation of H1N1 influenza A viruses. The notion that the avian HA is associated with preferential specificity for receptors with Siaalpha2,3Gal glycosidic linkage over those with Siaalpha2,6Gal linkage is not all consistent with the available data on H1N1 viruses. By x-ray crystallography, the HA structure of an avian H1N1 influenza A virus, as well as its complexes with the receptor analogs, was determined. The structures revealed no preferential binding of avian receptor analogs over that of the human analog, suggesting that the HA/receptor binding might not be as stringent as is commonly believed in determining the host receptor preference for some subtypes of influenza viruses, such as the H1N1 viruses. The structure also showed difference in glycosylation despite the preservation of related sequences, which may partly contribute to the difference between structures of human and avian origin.

PubMed: 19628241
DOI: 10.1016/j.virol.2009.06.028

実験手法

X-RAY DIFFRACTION (2.95 Å)