3HSC

THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN

Replaces:  2HSCReplaces:  1HSC

Summary for 3HSC

• Entry DOI: 10.2210/pdb3hsc/pdb
• Descriptor: HEAT-SHOCK COGNATE 7OKD PROTEIN, MAGNESIUM ION, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: hydrolase (acting on acid anhydrides)
• Biological source: Bos taurus (cattle)
• Cellular location: Cytoplasm (By similarity): P19120
• Total number of polymer chains: 1
• Total formula weight: 43105.49

Authors

Flaherty, K.M.,Deluca-Flaherty, C.R.,Mckay, D.B. (deposition date: 1995-03-24, release date: 1995-07-10, Last modification date: 2024-02-21)

Primary citation

Flaherty, K.M.,DeLuca-Flaherty, C.,McKay, D.B.
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein.
Nature, 346:623-628, 1990

PubMed Abstract: The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.

PubMed: 2143562
DOI: 10.1038/346623a0

Experimental method

X-RAY DIFFRACTION (1.93 Å)