3HSC

THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN

「2HSC」から置き換えられました 「1HSC」から置き換えられました

3HSC の概要

• エントリーDOI: 10.2210/pdb3hsc/pdb
• 分子名称: HEAT-SHOCK COGNATE 7OKD PROTEIN, MAGNESIUM ION, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: hydrolase (acting on acid anhydrides)
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm (By similarity): P19120
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43105.49

構造登録者

Flaherty, K.M.,Deluca-Flaherty, C.R.,Mckay, D.B. (登録日: 1995-03-24, 公開日: 1995-07-10, 最終更新日: 2024-02-21)

主引用文献

Flaherty, K.M.,DeLuca-Flaherty, C.,McKay, D.B.
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein.
Nature, 346:623-628, 1990

PubMed Abstract: The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.

PubMed: 2143562
DOI: 10.1038/346623a0

実験手法

X-RAY DIFFRACTION (1.93 Å)