3HRZ

Cobra Venom Factor (CVF) in complex with human factor B

Summary for 3HRZ

• Entry DOI: 10.2210/pdb3hrz/pdb
• Related: 3HS0
• Descriptor: Cobra venom factor, PHOSPHATE ION, Complement factor B, ... (11 entities in total)
• Functional Keywords: serine protease, glycosilated, multi-domain, complement system, convertase, complement alternate pathway, complement pathway, disulfide bond, glycoprotein, immune response, inflammatory response, innate immunity, secreted, thioester bond, cleavage on pair of basic residues, glycation, hydrolase, protease, sushi, zymogen, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q91132 Q91132 Q91132 P00751
• Total number of polymer chains: 4
• Total formula weight: 227037.21

Authors

Janssen, B.J.C.,Gomes, L.,Koning, R.I.,Svergun, D.I.,Koster, A.J.,Fritzinger, D.C.,Vogel, C.-W.,Gros, P. (deposition date: 2009-06-10, release date: 2009-07-07, Last modification date: 2023-09-06)

• Primary citation: Janssen, B.J.,Gomes, L.,Koning, R.I.,Svergun, D.I.,Koster, A.J.,Fritzinger, D.C.,Vogel, C.W.,Gros, P.; Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex; Embo J., 28:2469-2478, 2009; PubMed: 19574954; DOI: 10.1038/emboj.2009.184

Experimental method

X-RAY DIFFRACTION (2.2 Å)