3HRZ

Cobra Venom Factor (CVF) in complex with human factor B

3HRZ の概要

• エントリーDOI: 10.2210/pdb3hrz/pdb
• 関連するPDBエントリー: 3HS0
• 分子名称: Cobra venom factor, PHOSPHATE ION, Complement factor B, ... (11 entities in total)
• 機能のキーワード: serine protease, glycosilated, multi-domain, complement system, convertase, complement alternate pathway, complement pathway, disulfide bond, glycoprotein, immune response, inflammatory response, innate immunity, secreted, thioester bond, cleavage on pair of basic residues, glycation, hydrolase, protease, sushi, zymogen, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: Q91132 Q91132 Q91132 P00751
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 227037.21

構造登録者

Janssen, B.J.C.,Gomes, L.,Koning, R.I.,Svergun, D.I.,Koster, A.J.,Fritzinger, D.C.,Vogel, C.-W.,Gros, P. (登録日: 2009-06-10, 公開日: 2009-07-07, 最終更新日: 2023-09-06)

• 主引用文献: Janssen, B.J.,Gomes, L.,Koning, R.I.,Svergun, D.I.,Koster, A.J.,Fritzinger, D.C.,Vogel, C.W.,Gros, P.; Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex; Embo J., 28:2469-2478, 2009; PubMed: 19574954; DOI: 10.1038/emboj.2009.184

実験手法

X-RAY DIFFRACTION (2.2 Å)