3HRB

p38 kinase Crystal structure in complex with small molecule inhibitor

3HRB の概要

• エントリーDOI: 10.2210/pdb3hrb/pdb
• 分子名称: Mitogen-activated protein kinase 14, [3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone (3 entities in total)
• 機能のキーワード: p38 map kinase, transferase, inhibitor complex, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41552.32

構造登録者

Segarra, V.,Lumeras, W.,Vidal, B.,Leonard, P.,Fisher, M.,Lamers, M. (登録日: 2009-06-09, 公開日: 2009-09-01, 最終更新日: 2023-11-01)

• 主引用文献: Lumeras, W.,Caturla, F.,Vidal, L.,Esteve, C.,Balague, C.,Orellana, A.,Dominguez, M.,Roca, R.,Huerta, J.M.,Godessart, N.,Vidal, B.; Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase; J.Med.Chem., 52:5531-5545, 2009; PubMed: 19678708; DOI: 10.1021/jm9008604

実験手法

X-RAY DIFFRACTION (2.2 Å)