3HR5

M1prime peptide from IgE bound by humanized antibody 47H4 Fab

Summary for 3HR5

• Entry DOI: 10.2210/pdb3hr5/pdb
• Descriptor: Fab h47H4 light chain, Fab h47H4 heavy chain, M1prime-derived peptide, ... (5 entities in total)
• Functional Keywords: fab-peptide complex, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 12
• Total formula weight: 208103.77

Authors

Eigenbrot, C.W.,Ultsch, M.H. (deposition date: 2009-06-08, release date: 2010-05-19, Last modification date: 2011-07-13)

• Primary citation: Brightbill, H.D.,Jeet, S.,Lin, Z.,Yan, D.,Zhou, M.,Tan, M.,Nguyen, A.,Yeh, S.,Delarosa, D.,Leong, S.R.,Wong, T.,Chen, Y.,Ultsch, M.,Luis, E.,Ramani, S.R.,Jackman, J.,Gonzalez, L.,Dennis, M.S.,Chuntharapai, A.,DeForge, L.,Meng, Y.G.,Xu, M.,Eigenbrot, C.,Lee, W.P.,Refino, C.J.,Balazs, M.,Wu, L.C.; Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.; J.Clin.Invest., 120:2218-2229, 2010; PubMed: 20458139; DOI: 10.1172/JCI40141

Experimental method

X-RAY DIFFRACTION (2.4 Å)