3HR1
Discovery of novel inhibitors of PDE10A
Summary for 3HR1
Entry DOI | 10.2210/pdb3hr1/pdb |
Related | 3HQW 3HQY 3HQZ |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, SULFATE ION, 2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline, ... (6 entities in total) |
Functional Keywords | phosphodiesterase 10a, pde 10a, pde10 inhibitors, allosteric enzyme, alternative splicing, camp, camp-binding, cgmp, cgmp-binding, cytoplasm, hydrolase, magnesium, metal-binding, nucleotide-binding, zinc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Cytoplasm: Q9QYJ6 |
Total number of polymer chains | 1 |
Total formula weight | 44340.28 |
Authors | Pandit, J.,Marr, E.S. (deposition date: 2009-06-08, release date: 2009-08-04, Last modification date: 2023-09-06) |
Primary citation | Verhoest, P.R.,Chapin, D.S.,Corman, M.,Fonseca, K.,Harms, J.F.,Hou, X.,Marr, E.S.,Menniti, F.S.,Nelson, F.,O'Connor, R.,Pandit, J.,Proulx-Lafrance, C.,Schmidt, A.W.,Schmidt, C.J.,Suiciak, J.A.,Liras, S. Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia J.Med.Chem., 52:5188-5196, 2009 Cited by PubMed: 19630403DOI: 10.1021/jm900521k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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